Blood, 1959, Vol. 14, No. 6, pp. 654-661.
© 1959 American Society of Hematology, Inc.
Studies on Erythropoiesis. XIV. The Relationship of
Humoral Stimulation to Iron Absorption
SANFORD KRANTZ 1,
EUGENE GOLDWASSER 1, and
LEON O. JACOBSON 1
1 Argonne Cancer Research Hospital, operated by The University of Chicago
for the U. S. Atomic Energy Commission, and the Departments of Biochemistry and
Medicine, The University of Chicago, Chicago, Ill.
A new method for the study of gastrointestinal absorption of iron in
mice has been described. Phlebotomy, intravenous hemolysis, hypoxia and
cobaltous ion increase iron absorption. Transfusion-induced polycythemia
depresses iron absorption in mice. Iron-loading by means of Imferon also
depresses iron absorption. Under the conditions described for these experiments, exogenous plasma erythropoietin has no direct effect on iron absorption.
Submitted on August 27, 1958
Accepted on October 18, 1958
