Blood, 1959, Vol. 14, No. 5, pp. 564-570.
© 1959 American Society of Hematology, Inc.
Experimental Production of "Grape Cells" and Their
Relation to the Serum Gamma Globulin
and Seromucoids
AVINOAM ZLOTNICK 1,
CHAIM B. GERICHTER 1, and
ISAAC NIR 1
1 Department of Medicine, Division ‘A,’ and the Laboratory of Clinical Research, Rothschild Hadassah University Hospital, Jerusalem, Israel.
Hypenimmunization in rabbits with three different antigens produced an
elevation of the serum gamma globulin, a plasma cell proliferation and an
increase of the seromucoid content of the serum.
Grape cells and intracellular crystals were found in hyperimmune animals,
but not in controls. The globules of the grape cells stained positive with
periodic acid Schiff and with osmium tetroxide dissolved in a non-polar solution, indicating the presence of a mucopolysaccharide.
It is suggested that there is a relationship between the process of immunization—producing hyperglobulinemia, plasma cell hyperplasia and an elevation of the serum seromucoid content—and the presence of grape cells.
Submitted on January 24, 1958
Accepted on March 25, 1958
