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Blood, 1959, Vol. 14, No. 5, pp. 535-547.
© 1959 American Society of Hematology, Inc.

Nutritional Megaloblastic Anemia Associated with Sickle Cell States

ULFAR JONSSON 1, O. STUART ROATH 1, and CHARLOTTE I. F. KIRKPATRICK 1

1 Department of Medicine, University of Miami School of Medicine, and Jackson Memorial Hospital, Miami, Fla.

Three patients with megaloblastic anemia complicating sickle cell anemia or sickle cell-hemoglobin C disease are reported. Previously reported cases of megaloblastic anemia in patients with pre-existing hemolytic anemia are reviewed. It is concluded that the megaloblastic blood formation in such patients may be due to excessive need for folic acid or vitamin B12.

Submitted on July 23, 1958
Accepted on October 12, 1958


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