Blood, 1959, Vol. 14, No. 5, pp. 503-521.
© 1959 American Society of Hematology, Inc.
Autologous Bone Marrow Infusion as an Adjunct
in Therapy of Malignant Disease
WILLIAM MCFARLAND 1,
NORMA B. GRANVILLE 1, and
WILLIAM DAMESHEK 1
1 Blood Research Laboratory, a unit of the Ziskind Laboratories, New England
Center Hospital, and the Department of Medicine, Tufts University School of Medicine,
Boston, Mass.
1. Three patients with lymphosarcomatosis and two with disseminated
Hodgkin’s disease were treated with massive doses (super-dosage) of nitrogen mustard (over 1.0 mg./Kg.) given intravenously, followed by the intravenous infusion of autologous bone marrow.
2. Two of the five patients succumbed to infection. The remaining three
patients recovered within one month and experienced brief remissions.
3. It is suggested that this form of therapy merits further trial. Thus, it
may be considered for use earlier in the course of the disease when there
is a smaller total amount of tumor tissue, and thus a greater possibility for
its complete eradication. Its use in other neoplastic disorders, as following
operative procedures disclosing malignancy, is suggested.
Submitted on July 25, 1958
Accepted on September 26, 1958
