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Blood, 1959, Vol. 14, No. 4, pp. 399-408.
© 1959 American Society of Hematology, Inc.


Normal Functions of the Spleen Relative to Red Blood Cells: A Review

WILLIAM H. CROSBY 1

1 Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

During all the stages of a red cell’s life the normal spleen exerts a normal function. Eight of these functions have been considered: (1) erythropoiesis; (2) an effect upon red cell production; (3) an effect upon maturation of the red cell surface; (4) the reservoir function; (5) the "culling function"; (6) iron turnover and storage; (7) the "pitting function"; (8) destruction of old red cells.

Submitted on June 13, 1958
Accepted on June 16, 1958


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