Blood, 1959, Vol. 14, No. 2, pp. 170-186.
© 1959 American Society of Hematology, Inc.
The Pelger-Huët Anomaly in Three Families and Its Use
in Determining the Disappearance of Transfused
Neutrophils from the Peripheral Blood
WENDELL F. ROSSE 1 and
CLIFFORD W. GURNEY 1
1 Argonne Cancer Research Hospital, USAEC, and the Department of Medicine,
The University of Chicago, Illinois.
1. Thirteen cases of Pelger-Huët anomaly occurring in three families are
presented and discussed. The second recorded case of the anomaly in Negroes
is included; the occurrence of familial hereditary elliptocytosis in this same
family and the possible relationship to the Pelger-Huët anomaly are discussed.
2. Certain less well-known facts about Pelger-Huët anomaly are considered
in relation to the cases presented.
3. The survival time of transfused neutrophils in the peripheral blood was
investigated using the anomaly as a tagging device. Most of the cells were
found to be absent from the peripheral blood stream in 6 to 8 hours, and
none was found after 49.5 hours.
Submitted on May 19, 1958
Accepted on July 22, 1958
