Blood, 1959, Vol. 14, No. 12, pp. 1302-1321.
© 1959 American Society of Hematology, Inc.
Observations on Chimpanzees after Whole-Body Radiation
and Homologous Bone Marrow Treatment
HARVEY ROTHBERG 1,
EUGENE B. BLAIR 1,
ALPHONSE C. GOMEZ 1, and
WILBUR MCNULTY 1
1 Department of Hematology, Walter Reed Army Institute of Research, Walter
Reed Army Medical Center, Washington, D. C.
1. Three chimpanzees were given 900 r of whole body radiation followed
by transfusion of homologous bone marrow. One animal survived for nearly
six months.
2. Five chimpanzees were given 1200 r of whole body radiation; three of
them were given homologous bone marrow. There was no difference in survival
time of treated animals and of controls.
3. Observations were made on clinical, hematologic, bacteriologic and
pathologic aspects of acute radiation injury.
4. There was no evidence of a "take" of the homologous marrow. The
significance of the findings is discussed.
Submitted on November 19, 1958
Accepted on March 18, 1959
