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Blood, 1959, Vol. 14, No. 11, pp. 1180-1186.
© 1959 American Society of Hematology, Inc.


Observations on Heinz Bodies in Normal and Splenectomized Rabbits

HARVEY ROTHBERG 1, LEON A. CORALLO 1, and WILLIAM H. CROSBY 1

1 Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

The disappearance from the circulation of Heinz bodies, produced by incubation of blood with phenylhydrazine, was studied in normal and splenectomized rabbits. In the intact animal, red cells damaged by this procedure are removed largely by the spleen. In both intact and splenectomized rabbits, the Heinz bodies are withdrawn from the circulation by removal in toto of the red cells containing them.

Submitted on January 9, 1959
Accepted on June 1, 1959


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