Blood, 1959, Vol. 14, No. 10, pp. 1112-1127.
© 1959 American Society of Hematology, Inc.
Anomalous Panleukocytic Granulation
LUIZ GONZAGA SARAIVA 1,
MIECIO AZEVEDO 1,
JOSÉ MAURICIO CORREA 1,
GERSON CARVALHO 1, and
JOSÉ DONATO PROSPERO 1
1 Children’s Hospital of the Brazilian Red Cross and Central Laboratory of
Santa Casa de Misericórdia, São Paulo, Brazil.
Anomalous panleukocytic granulation is described in the peripheral blood,
bone marrow and spleen of a 3 year old girl. Myeloid leukocytes showed
giant peroxidase and Sudan Black B-positive granules. Lymphocyte corpuscles were positive in the periodic acid-Schiff test. Deviations in the
structure and segmentation of the neutrophil nuclei were observed. Increase
of gamma globulins and decrease of lipoproteins were found in the blood
serum.
Hepatosplenomegaly, psychomotor underdevelopment, respiratory tract infections, roentgenologic changes of bones, lungs and heart were also found.
The parents were first cousins, and anomalous corpuscles were seen in the
father’s lymphocytes.
At necropsy diffuse or focal infiltration of the organs by lymphoid, plasma
and reticular cells suggested a systemic condition.
Submitted on July 26, 1958
Accepted on April 11, 1959
