Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HEUSON, J. C.
Right arrow Articles by TAGNON, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HEUSON, J. C.
Right arrow Articles by TAGNON, H. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1958, Vol. 13, No. 9, pp. 874-882.
© 1958 American Society of Hematology, Inc.

A New Diagnostic and Therapeutic Approach Fibrinolysis and Hemorrhage

J. C. HEUSON 1, W. PEERS 1, and H. J. TAGNON 1

1 Department of Medicine and Clinical Investigation, Institut Jules Bordet, Centre Anticancéreux de l’Université de Bruxelles, and the Department of Obstetrics and Gynecology, Hopital Saint-Pierre, Brussels, Belgium.

1. The case is presented of a patient who underwent a cesarean section during which cardiac arrest occurred. Cardiac massage was successful in reestablishing normal heart action.

2. A severe hemorrhagic diathesis associated with fibrinolysis appeared during the period of shock associated with cardiac arrest.

3. The plasma of the patient obtained during the period of fibrinolysis was able to digest its own fibrin as well as a substrate of casein marked with radioactive iodine.

4. A new method of measurement of fibrinolysis based on the use of tagged casein is presented: the main advantage of this method is that the substrate is not contaminated with plasminogen or plasmin. In addition the products of the reaction are measured by their radioactivity. Therefore, the blank and readings in this method depend solely upon the substrate and are not contributed to by the other reagents used.

5. The proteolytic activity of the plasma from a patient with fibrinolysis was shown to be inhibited by the trypsin inhibitor from soy bean.

6. The intravenous injection of trypsin inhibitor in this patient was followed by the disappearance of fibrinolysis in her blood.

Submitted on October 24, 1957
Accepted on March 25, 1958


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
E. E. Mandel, C. P. Maurizi, E. M. Katz, J. Lazerson, and A. D. Lieberman
Lipemia-Induced Acceleration of Intravascular Clotting: III. Correlation with Thrombelastography
Angiology, September 1, 1962; 13(9): 435 - 443.
[PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1958 by American Society of Hematology         Online ISSN: 1528-0020