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Blood, 1958, Vol. 13, No. 8, pp. 763-772.
© 1958 American Society of Hematology, Inc.

The Detection of Minor Erythrocyte Populations by Mixed Agglutinates

A. RICHARDSON JONES 1 and SHEILA SILVER 1

1 Blood Grouping Laboratory of Boston and the Department of Pediatrics, Harvard Medical School.

The principle of the "mixed agglutination" reaction has been applied to the development of a technic for the detection of minor populations of erythrocytes in mixtures in which the minor component is identifiable by means of one or another of the blood group iso-antigens. The method lends itself to the quantification of a minor population and provides a degree of sensitivity which compares very favorably with that which can be achieved through the use of radioactive tracers.

Submitted on December 10, 1957
Accepted on January 16, 1958


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