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Blood, 1958, Vol. 13, No. 8, pp. 740-747.
© 1958 American Society of Hematology, Inc.

Identification of the Vitamin B12-Binding Protein in the Serum of Normals and of Patients with Chronic Myelocytic Leukemia

ROBERT S. MENDELSOHN 1, DONALD M. WATKIN 1, ANN P. HORBETT 1, and JOHN L. FAHEY 1

1 Nutrition and Metabolism Service, National Cancer Institute, N.I.H., P. H. S., D. H. E. & W., Bethesda, Maryland.

Vitamin B12-binding proteins in the serum of normal subjects and of patients with chronic myelocytic leukemia have been compared. The in-vivo-bound B12 was utilized to identify the binding protein. Column protein chromatography and block and paper electrophoresis were employed individually and in combination to characterize the B12-binding protein.

B12 was found to be bound primarily to an alpha-l globulin in both normal individuals and in patients with chronic myelocytic leukemia. No qualitative difference was found in these proteins.

The increased amounts of B12-binding protein in the serum of patients with chronic myelocytic leukemia would seem to be attributable to abnormal metabolism of the same protein that binds B12 in normal serum.

Submitted on December 2, 1957
Accepted on February 5, 1958


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 Arch Intern MedHome page
R. P. BRITT and D. P. ROSE
Pernicious Anemia With a Normal Serum Vitamin B12 Level in a Case of Chronic Granulocytic Leukemia
Arch Intern Med, January 1, 1966; 117(1): 32 - 33.
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