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1 Department of Medicine, University of Wisconsin School of Medicine, Madison,
Wis. and the National Cancer Institute, National Institutes of Health, Bethesda, Md.
A case of chronic erythroleukemia is reported in which a picture of chronic
granulocytic leukemia preceded the erythremic proliferation by one to three
years. The patient was followed throughout his entire 10-year course and
the clinical impressions were confirmed initially by biopsy and eventually
at necropsy. The rare examples of this occurrence usually cited in the literature are
reviewed and briefly discussed. In every case the development of erythremia
was preceded by radiation therapy for the leukemic dyscrasia. A set of criteria for evaluating such cases in order to provide definite evidence for this sequence of events is suggested. The transformation of chronic granulocytic leukemia into polycythemia
vera or chronic erythroleukemia lends further support to the concept of
fundamental similarity and close inter-relation of these myeloproliferative
disorders.
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