Blood, 1958, Vol. 13, No. 5, pp. 492-501.
© 1958 American Society of Hematology, Inc.
Hemoglobin H-Thalassemia Disease
JAMES A. WOLFF 1,
RICHARD H. MICHAELS 1, and
FREDERICK H. VON HOFE 1
1 Department of Pediatrics, Columbia University, and the Babies Hospital
New York City, N. Y.
A child of Italian parentage is presented as an example of Hgb H-thalassemia disease. A family study is included. Previous documented reports have
included individuals of Chinese, Thai, Greek and Filipino parentage. Genetic
aspects of the association of Hgb H with thalassemia are discussed. It is
suggested that the study of other patients who present a clinical picture
resembling mild Cooleys anemia may reveal the presence of hemoglobin
variants.
Submitted on September 14, 1957
Accepted on November 25, 1957