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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by WILSON, S. J. Articles by ENS, G. G. Search for Related Content PubMed PubMed Citation Articles by WILSON, S. J. Articles by ENS, G. G. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1958, Vol. 13, No. 5, pp. 483-491. © 1958 American Society of Hematology, Inc. Blood Coagulation in Acute Iron Intoxication SLOAN J. WILSON 1, HELEN E. HEATH 1, PAUL L. NELSON 1, and G. GEORGE ENS 1 1 Hematology Section, Department of Medicine, University of Kansas Medical Center, Kansas City. Acute intestinal iron intoxication was produced in rabbits and the levels of serum were correlated with changes in blood coagulation. Acute intestinal iron intoxication resulted in a prolongation of the coagulation time or a complete absence of coagulation, thrombocytopenia, hypoprothrombinemia, and qualitative changes in the fibrinogen. Clot retraction was decreased to absent. The most marked defect occurred in fibrinogen. In the postiron period the fibrin clot was rust-colored, friable, and fragmented easily. The iron content of the fibrin was tremendous. The physiologic activity of the fibrinogen was decreased and coagulation prolonged. Fibrinolytic studies revealed no increase in the lysis of the fibrin. The decrease in the physiologic activity of the fibrinogen frequently produced a hemorrhagic level of prothrombin as measured by the one-stage method. The prothrombin as measured by the two-stage method, although decreased, was not in the hemorrhagic zone. Modification of the one-stage method, correlated with the prothrombin values as determined by the two-stage technic, revealed a defect in both prothrombin and fibrinogen. Submitted on August 15, 1957 Accepted on November 5, 1957 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. R. Walsh and J. B. Gillick Iron Chelation in Acute Iron Poisoning and Chronic Hypersiderosis Clinical Pediatrics, November 1, 1965; 4(11): 633 - 638. [Abstract] [PDF]

	Copyright © 1958 by American Society of Hematology         Online ISSN: 1528-0020