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Blood, 1958, Vol. 13, No. 5, pp. 457-463.
© 1958 American Society of Hematology, Inc.

Enhanced Urinary Excretion of Co60 Vitamin B12 Produced by Delayed Release Capsules

P. C. JOHNSON 1 and E. S. BERGER 1

1 Radioisotope Service, V.A. Hospital and Department of Medicine, University of Oklahoma, Oklahoma City.

1. Patients without known hematologic disease were given 8 µg. (0.2 µc. Co60 vitamin B12 as a water solution or in various types of delayed release capsules.

2. All groups showed approximately equal fecal excretion. However, the cobalt60-labeled vitamin B12 delayed release capsules showed a greater urinary excretion after a loading dose of stable B12 than did the water solution of labeled vitamin B12.

Submitted on March 4, 1957
Accepted on November 25, 1957


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