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Blood, 1958, Vol. 13, No. 4, pp. 382-397.
© 1958 American Society of Hematology, Inc.

A Circulating Inhibitor (Anti-AcG) Specific for the Labile Factor-V of the Blood-Clotting Mechanism

JOHN H. FERGUSON 1, CHARLES L. JOHNSTON JR. 1, and DORIS A. HOWELL 1

1 Department of Physiology, University of North Carolina, Chapel Hill, and the Department of Pediatrics, Duke University, Durham, North Carolina.

Study of the present hemorrhagic disorder establishes, without doubt, the presence of a powerful specific anti-AcG. The deprivation of AcG due to this inhibitor confirms the view that the labile factor plays a key role in the blood clotting system in at least two phases, namely, (1) during thromboplastin generation, and (2) later, during the conversion of prothrombin to thrombin. AcG is an essential component of many special clotting-test systems.

Submitted on August 29, 1957
Accepted on November 18, 1957


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