Blood, 1958, Vol. 13, No. 4, pp. 376-381.
© 1958 American Society of Hematology, Inc.
Critique of the Concept of the "Pre-L.E." Cell
FRANCES PASCHER 1 and
ALEXANDER BOROTA 1
1 Department of Dermatology and Syphilology of the Post-Graduate Medical
School of the New York University Bellevue Medical Center (Dr. Marion B. Sulzberger,
Chairman), and the Skin and Cancer Unit of the New York University Hospital.
1. Cells with morphologic features apparently identical with the so-called
pre-L.E. cell were demonstrated in L.E. preparations in healthy subjects and
in individuals suffering from diverse cutaneous and visceral disorders, as
well as in patients with systemic lupus erythematosus.
2. These cells appear to be decomposition forms without diagnostic significance, resulting from nonspecific autolytic process that sets in and progresses in the course of setting up the L.E. preparation.
Submitted on July 13, 1957
Accepted on November 2, 1957
