Blood, 1958, Vol. 13, No. 4, pp. 339-347.
© 1958 American Society of Hematology, Inc.
Absorption of Cobalt60-Labeled Vitamin B12 After
Subtotal Gastrectomy
FRITZ LOEWENSTEIN 1
1 Radioisotope and Medical Services, Boston Veterans Administration Hospital,
and the Department of Medicine, Boston University School of Medicine, Boston, Mass.
Vitamin B12 absorption has been studied in patients with subtotal gastrectomy by means of the Co60 B12 urinary excretion test. Five patients tested
before and after a conventional subtotal gastrectomy showed no significant
change in absorption.
Of 22 patients who were tested at various intervals after a conventional
(distal) subtotal gastrectomy, 19 had normal vitiamin B12 absorption and
three had low absorption that was corrected to normal by giving gastric
juice with the test dose. Three patients who had had a proximal gastrectomy
showed normal vitamin B12 absorption, indicating that intrinsic factor was
being produced by the remaining distal portion of the stomach.
Submitted on June 27, 1957
Accepted on November 1, 1957