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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by BLANCHAER, M. C. Articles by HOLLENBERG, M. J. Search for Related Content PubMed PubMed Citation Articles by BLANCHAER, M. C. Articles by HOLLENBERG, M. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1958, Vol. 13, No. 3, pp. 245-257. © 1958 American Society of Hematology, Inc. Plasma Lactic Dehydrogenase and Phosphohexose Isomerase in Leukemia M. C. BLANCHAER 1, P. T. GREEN 1, J. P. MACLEAN 1, and M. J. HOLLENBERG 1 1 Departments of Biochemistry and Medicine, St. Boniface Hospital, St. Boniface, Manitoba; and the Department of Physiology and Medical Research and the Department of Medicine, University of Manitoba, Winnipeg, Canada. Two enzymes, lactic dehydrogenase (LD) and phosphohexose isomerase (PHI), were measured in the plasma of 30 patients with leukemia and compared with the findings in 66 control subjects. Abnormally elevated PHI levels were found in both acute and chronic myelocytic leukemia, but not in lymphocytic leukemia. The plasma LD was increased above normal in acute and chronic myelocytic leukemia, in acute lymphocytic, but not in chronic lymphocytic leukemia. Both enzymes were normal or only slightly raised in three patients with the aleukemic type of the disease. Hemolytic anemia in seven leukemic patients was associated with high plasma LD values in the presence of relatively low PHI levels. Results of serial enzyme studies from the time of diagnosis until death indicated that both plasma enzymes, but especially the LD, usually reflected changes in the course of the disease-falling during remissions and rising during relapses. In most cases this enzyme paralleled the leukocyte level but occasionally indicated the onset of a relapse or remission before the white cell count had begun to change. Submitted on June 28, 1957 Accepted on November 18, 1957 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. KABAKOW, W. ANTOPOL, H. G. ALBAUM, G. BLINICK, L. GINZBURG, and R. YOUNG Serum Enzyme Changes During Treatment of Cancer Arch Intern Med, September 1, 1962; 110(3): 331 - 338. [Abstract] [PDF]

	Copyright © 1958 by American Society of Hematology         Online ISSN: 1528-0020