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Blood, 1958, Vol. 13, No. 3, pp. 239-244.
© 1958 American Society of Hematology, Inc.

Effect of Indole Compounds on Vitamin B12 Utilization

JERRY DREXLER 1

1 Department of Clinical Pathology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute, Cleveland, Ohio.

Indole and indoleacetic acid are shown to inhibit the growth of a vitamin B12 dependent microorganism, a mutant strain of Escherichia coli. It is suggested that the mechanism of that inhibition may be a competitive inhibition of some enzymatic system necessary for the utilization of vitamin B12.

Submitted on July 11, 1957
Accepted on September 19, 1957


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