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Blood, 1958, Vol. 13, No. 2, pp. 162-176.
© 1958 American Society of Hematology, Inc.

The Pathogenesis of Transferred Chloroleukemia in the Albino Rat

CHARLES HARRIS 1, WILLIAM T. BURKE 1, MARGOT GRUENSTEIN 1, and HARRY SHAY 1

1 Fels Research Institute, Temple University School of Medicine, Philadelphia 40, Pa.

The pathogenesis of transferred chloroleukemia in the rat was studied and the following results were derived. This type of leukemia colonized in an orderly manner, after intraperitoneal inoculation of leukemic cells, first in the retroperitoneal fat, then almost simultaneously in liver, spleen, lungs, and bone marrow. Only after the leucocyte pool was saturated with leukemic cells did the peripheral blood show an increase in both abnormal and normal components.

Submitted on July 1, 1957
Accepted on September 15, 1957


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