Blood, 1958, Vol. 13, No. 12, pp. 1168-1175.
© 1958 American Society of Hematology, Inc.
Modification of X. radiation Lethality by Autologous
Marrow Infusion in Dogs
EDWARD L. ALPEN 1 and
S. J. BAUM 1
1 U. S. Naval Radiological Defense Laboratory, San Francisco, Calif.
Dogs have been treated after x-irradiation with doses of 400 r and 600 r by
injection of either homologous or autologous bone marrow. The bone marrow
was obtained by preirradiation biopsy and was reinjected either into the
animal from which it was drawn (autologous) or into an alternate recipient
(homologous). Injection of 2 x 109 autologous nucleated cells successfully
protected all dogs given either 400 r or 600 r. Dogs given 1 x 109 autologous
nucleated cells after 600 r failed to survive. No protection was provided by
injection of 2 x 109 homologous nucleated cells after 400 r nor by injection of
2 x 109 or 5 x 109 homologous nucleated cells after 600 r. It is proposed that a
differential species sensitivity to foreign cell implants accounts for the failure
of homologous marrow infusions in dogs in contradistinction to the protection
provided by homologous or heterologous marrow implants in rats and mice,
and by homologous implants in monkeys.
Submitted on March 19, 1958
Accepted on May 31, 1958
