Blood, 1958, Vol. 13, No. 1, pp. 79-84.
© 1958 American Society of Hematology, Inc.
Studies on the Etiology of the Elevated Serum Isomerase
in Chronic Myelocytic Leukemia
L. G. ISRAELS 1,
G. E. DELORY 1,
L. HNATIUK 1, and
E. FRIESEN 1
1 Department of Biochemistry, Faculty of Medicine, University of Manitoba,
and the Manitoba Cancer Institute, Winnipeg, Canada.
1. The phosphohexose isomerase activity of the serum of patients with chronic
myelocytic leukemia closely parallels the rise and fall in total granulocyte count.
2. Its separated leukocytes the isomerase activity of the granulocytes was
found to be approximately three times that of the lymphocytes.
3. The serum isomerase activity was estimated in dogs with induced leukocytosis and leukopenia. The enzyme activity bore a closer relationship to leukocyte destruction than to leukocyte production.
4. These findings suggest that the elevated serum phosphohexose isomerase
activity found in patients with chronic myelocytic leukemia probably originates
from disintegrating granulocytes.
Submitted on May 1, 1957
Accepted on September 17, 1957
