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Blood, 1958, Vol. 13, No. 1, pp. 55-60.
© 1958 American Society of Hematology, Inc.

Studies on Erythropoiesis

V. The Effect of Cobalt on the Production of Erythropoietin

EUGENE GOLDWASSER 1, LEON O. JACOBSON 1, WALTER FRIED 1, and LOUIS F. PLZAK 1

1 Argonne Cancer Research Hospital, USAEC, and the Departments of Biochemistry and Medicine, The University of Chicago, Chicago, Ill.

It has been shown that plasma from animals that have been injected with cobaltous chloride rapidly develops a high titer of erythropoietin.

The gross properities of the active material appear to be the same from cobalt-treated as from phenylhydrazine-treated animals.

Other metal ions and a complex ion have been studied as stimulants for erythropoietin formation; none was as effective as cobaltous ion with the exception of cobaltic hexamine.

Submitted on May 6, 1957
Accepted on September 20, 1957


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