Blood, 1957, Vol. 12, No. 9, pp. 788-803.
© 1957 American Society of Hematology, Inc.
Leukemia or Lymphoma and Coexistent Primary Malignant
Lesions: A Review of the Literature and a Study
of 120 Cases
CHARLES G. MOERTEL 1 and
ALBERT B. HAGEDORN 1
1 Mayo Clinic and Mayo Foundation, Rochester, Minnesota (a part of the
Graduate School of the University of Minnesota).
A total of 194 cases of leukemia or lymphoma with coexistent primary malignant disease was found reported in the literature. To this we have added 120 new
cases from the files of the Mayo Clinic in which the diagnosis was made in the
10 years from 1944 through 1953.
The following observations were made:
1. The presence of leukemia or lymphoma does not seem to predispose to the
development of any other specific type of primary malignancy.
2. The incidence of another primary malignant lesion in patients with leukemia or lymphoma is probably comparable to, and perhaps exceeds, that in any
segment of the general population of similar age.
3. The coexistence of Kaposi’s sarcoma and leukemia or lymphoma in the
same patient probably represents a morphologic variation of the same basic
malignant disease of the reticuloendothelial system.
4. Any patient with leukemia or lymphoma who presents signs or symptoms
of a focal malignant lesion should be regarded as having another primary lesion
until proved otherwise on pathologic examination.
Submitted on December 10, 1956
Accepted on January 27, 1957
