Blood, 1957, Vol. 12, No. 8, pp. 755-765.
© 1957 American Society of Hematology, Inc.
Therapeutic Results in Treatment of Hodgkin’s Disease
with CB 1348 and R-48
ANTONIO ROTTINO 1
1 Hodgkin’s Disease Research Laboratory and The Department of Medicine of
St. Vincent’s Hospital, New York, N. Y.
Forty patients with Hodgkin’s disease were treated with CB 1348 or R-48 or
both. These drugs are useful and easy to administer. They have a therapeutic
effect upon subjective symptoms and enlarged lymph nodes. The average remission lasts two months, shorter in some cases and longer in other cases. Toxicity
is minimal. Hematologic depression occurs late as a rule and is reversible upon
discontinuance of the drugs. Both drugs appeared to produce the same effect at
about the same rate, and the effect lasted for about the same length of time.
R-48 proved effective in some instances where CB 1348 had not been so, and
CB 1348 sometimes induced a remission when T. E. M. had failed. In some cases
radiation therapy caused recession of nodes when both drugs had been ineffective.
Submitted on November 29, 1956
Accepted on February 2, 1957
