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Blood, 1957, Vol. 12, No. 7, pp. 635-643.
© 1957 American Society of Hematology, Inc.


Quantitative Plasma Amino Acid Values in Leukemic Blood

JOHN J. KELLEY 1 and HARRY A. WAISMAN 1

1 Department of Pediatrics, University of Wisconsin Medical School.

1. Quantitative methods for analysis of free amino acids in plasma have been performed on blood from normal and leukemic individuals.

2. An increase in the glutamic acid phenylalanine and "leucine" levels was found in the blood plasma of patients with acute leukemia.

3. Both the chronic myelogenous and the chronic lymphatic leukemia patients had high levels of glutamic acid, phenylalanine, alanine and proline.

4. Lower than normal levels of asparagine and threonine were found in the plasma of patients with acute leukemia.

Submitted on October 26, 1956
Accepted on December 1, 1956


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H. A. Waisman and H. F. Harlow
Experimental Phenylketonuria in Infant Monkeys: A high phenylalanine diet produces abnormalities simulating those of the hereditary disease
Science, February 12, 1965; 147(3659): 685 - 695.
[Abstract] [PDF]



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