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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by VAN DYKE, D. C. Articles by EVANS, H. M. Search for Related Content PubMed PubMed Citation Articles by VAN DYKE, D. C. Articles by EVANS, H. M. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1957, Vol. 12, No. 6, pp. 539-548. © 1957 American Society of Hematology, Inc. The Separate Existence of the Pituitary Erythropoietic Hormone DONALD C. VAN DYKE 1, M. E. SIMPSON 1, A. N. CONTOPOULOS 1, and H. M. EVANS 1 1 Institute of Experimental Biology, University of California, Berkeley. Although it is recognized that a number of factors are involved in the mechanism controlling red blood cell production, the anterior pituitary furnishes one factor of importance. This pituitary factor is apparently a hormone distinct from other trophic hormones. It is allied chemically only to ACTH and yet both biological and chemical evidence indicates that the pituitary erythropoietic hormone and ACTH are not the same. The major problem in further elucidating the role of the pituitary in the control of erythropoiesis resolves itself into developing a satisfactory method of preparation of erythropoietic hormone which will separate it from ACTH. It is true that no ACTH preparation has been made which does not possess some erythropoietic activity, and no pituitary erythropoietic hormone has been prepared which is entirely devoid of ACTH. Nevertheless, the proportion of these two activities in different preparations has varied so greatly as to assure their separate existence. Autolytic digestion consistently reduces the ACTH activity, while erythropoietic activity is retained. It has been found that oxycellulose is a better adsorbent of ACTH than of erythropoietic hormone. These observations add chemical evidence to the accumulated biological evidence establishing the separate existence of these two pituitary principles. Submitted on October 5, 1956 Accepted on November 20, 1956 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. DEMULDER Iron: Metabolism, Biochemistry, and Clinical Pathological Physiology-- Review of Recent Literature Arch Intern Med, August 1, 1958; 102(2): 254 - 301. [Abstract] [PDF]

	Copyright © 1957 by American Society of Hematology         Online ISSN: 1528-0020