Blood, 1957, Vol. 12, No. 4, pp. 391-397.
© 1957 American Society of Hematology, Inc.
Chronic Myelosis Following the Use of Thorotrast
M. NETOU
EK 1,
J. BORE 1, and
K. DVO
ÁK 1
1 First Clinic of Internal Medicine, Charles University, Prague, and Department
of Radiology and Internal Medicine, Tábor Hospital, Czechoslovakia.
Following hepatolienography which was carried out in a woman aged 52 in
1931, for a tumor of the right kidney which was removed at operation, chronic
myelosis developed in 1954. This was remarkable for the absence of splenomegaly, a relatively mild course and a paradoxic reaction to x-ray irradiation of
the spleen, when instead of the expected decrease there was a doubling in the
number of leukocytes. A causal relationship of myeloid leukemia to the thorotrast administered 23 years previously cannot be excluded.
Submitted on June 8, 1956
Accepted on September 20, 1956
