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Blood, 1957, Vol. 12, No. 4, pp. 347-354.
© 1957 American Society of Hematology, Inc.


A Modified Urinary Excretion Test for Measuring Oral Cobalt60 Labeled Vitamin B12 Absorption and its Application in Certain Disease States

AARON MILLER 1, HOWARD F. CORBUS 1, and JOHN F. SULLIVAN 1

1 Radioisotope and Medical Service, Boston veterans Administration Hospital, and the Departments of Medicine, Boston University School of Medicine and Tufts University School of Medicine, Boston, Massachusetts.

1. Factors relating to the urinary excretion test for oral vitamin B12 absorption were studied. A modified procedure is presented giving a high percentage of urinary recovery of radioactivity in the normal.

2. Values in the pernicious anemia range were found in the presence of acute infection and severe renal insufficiency. Other limitations in the interpretation of the test are discussed.

Submitted on July 31, 1956
Accepted on October 7, 1956


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