Blood, 1957, Vol. 12, No. 2, pp. 165-170.
© 1957 American Society of Hematology, Inc.
Siderocytes and the Spleen
WILLIAM H. CROSBY 1 and
NAOMI H. BENJAMIN 1
1 Department of Hematology, Walter Reed Army Institute of Research, Walter
Reed Army Medical Center, Washington, D. C.
1. Blood containing high concentrations of siderocytes was transfused into
four recipients with spleens and into two who lacked a spleen. In the circulation
of recipients with spleens the siderin granules rapidly disappeared while the
transfused red cells remained. In the recipients who had no spleen both the
granules and the red cells remained.
2. It is concluded that the spleen is somehow able to bring about the removal
of siderin inclusion bodies without destroying the red cells that contain them.
Submitted on May 28, 1956
Accepted on June 26, 1956
