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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by BERLIN, N. I. Articles by ELMLINGER, P. J. Search for Related Content PubMed PubMed Citation Articles by BERLIN, N. I. Articles by ELMLINGER, P. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1957, Vol. 12, No. 2, pp. 147-164. © 1957 American Society of Hematology, Inc. Recent Advances in the Knowledge of Total Red Cell Volume, Production and Destruction NATHANIEL I. BERLIN 1, JOHN H. LAWRENCE 1, and PAUL J. ELMLINGER 1 1 Donner Laboratory and Donner Pavilion, University of California, Berkeley, Calif. Since anemia or polycythemia can result only from a change in rate of formation of red cells or a change in the life span of the red cells, a determination of the total red cell volume, Fe59 studies to estimate the rate and site of production of red cells, and C14-labeled glycine or Fe59 studies to determine the life span of red cells permit a description of the pathogenesis of any alterations in the erythropoietic state. This has been of great value in clinical hematology from the stand-point of understanding the basic nature of the various diseases and, in particular, the selection of patients with unusual anemias possibly related to hypersplenism who might benefit from splenectomy. Splenic erythropoiesis can be easily differentiated from splenic red cell destruction. Since two of these methods—the determination of the blood volume and the Fe59 studies—are now possible in general commumnity hospitals and since modifications of the Fe59 method permit the determination of the life span of the red cell, adequate evaluation of the erythropoietic state is now possible in general hospitals. Submitted on May 23, 1956 Accepted on August 6, 1956 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. S. BLUM and M. J. ZBAR Relative Polycythemia: Alterations of Red Cell Distribution Simulating Hemoconcentration Arch Intern Med, September 1, 1959; 104(3): 385 - 389. [Abstract] [PDF]

	Copyright © 1957 by American Society of Hematology         Online ISSN: 1528-0020