Blood, 1957, Vol. 12, No. 12, pp. 1101-1113.
© 1957 American Society of Hematology, Inc.
The Mode of Action and Nature of a Heat Stable Plasma
Erythropoietic Factor
WALTER A. RAMBACH 1,
HOWARD L. ALT 1, and
JOHN A. D. COOPER 1
1 Departments of Medicine and Biochemistry, Northwestern University Medical
School, Chicago, Illinois.
Boiled filtrates of "anemic" rabbit plasma have been studied by physicochemical means, and the response to their injection into the rat has been followed
utilizing tracer and morphologic technics. It has been demonstrated that the
erythropoietic activity of these filtrates is associated with an alpha-2 globulin,
most probably a mucoprotein; and that this material produces, in the rat, an
increase in the rate of red cell division and maturation, and an acceleration of
release of these cells from the bone marrow and accessory organs of hemopoiesis.
Submitted on February 11, 1957
Accepted on August 15, 1957
