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 Blood, 15 October 2008, Vol. 112, No. 8, pp. 3135-3137.
Prepublished online as a Blood First Edition Paper on June 27, 2008; DOI 10.1182/blood-2008-04-153783.

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CLINICAL TRIALS AND OBSERVATIONS

Brief Report

Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia

Alessandra Carobbio1, Guido Finazzi2, Elisabetta Antonioli3, Paola Guglielmelli3, Alessandro M. Vannucchi3, Federica Delaini1, Vittoria Guerini1, Marco Ruggeri4, Francesco Rodeghiero4, Alessandro Rambaldi1, and Tiziano Barbui1

Departments of1 Hematology and 2 Transfusion Medicine, Ospedali Riuniti di Bergamo, Bergamo; 3 Department of Hematology, Università degli Studi di Firenze, Firenze; and 4 Department of Hematology, Ospedale San Bortolo, Vicenza, Italy

To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2V617F mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients. We found that a platelet count at diagnosis greater than 1000 x 109/L was associated with significantly lower rate of thrombosis in multivariable analysis and, if combined with leukocytes less than 11 x 109/L, pointed to a "low-risk" category with a rate of thrombosis of 1.59% of patients/year. On the contrary, the highest risk category (thrombosis rate, 2.95% of patients/year) was constituted of patients with leukocytosis, lower platelet count, and a JAK2V617F mutated genotype in most cases (77% vs 26% in the low-risk group), independently from standard risk factors. These data challenge the theory that elevated platelet count increases thrombosis risk in ET and suggest prospective clinical trials to support this hypothesis.


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Related Articles in Blood Online:

Platelet count in essential thrombocythemia: the more the better?
Ayalew Tefferi
Blood 2008 112: 3526. [Full Text] [PDF]

Response: Thrombocytosis in low-risk ET patients
Tiziano Barbui, Alessandra Carobbio, and Guido Finazzi
Blood 2008 112: 3526-3527. [Full Text] [PDF]





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