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Blood, 1 October 2008, Vol. 112, No. 7, pp. 2709-2712. Prepublished online as a Blood First Edition Paper on July 1, 2008; DOI 10.1182/blood-2008-04-147884. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-04-147884v1 112/7/2709    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Sarasquete, M. E. Articles by San Miguel, J. F. PubMed PubMed Citation Articles by Sarasquete, M. E. Articles by San Miguel, J. F. Related Collections Neoplasia Brief Reports Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief Report Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis Maria E. Sarasquete1,*, Ramon García-Sanz13,*, Luis Marín1, Miguel Alcoceba1, Maria C. Chillón1,2, Ana Balanzategui1, Carlos Santamaria1, Laura Rosiñol3, Javier de la Rubia3, Miguel T. Hernandez3, Inmaculada Garcia-Navarro3, Juan J. Lahuerta3, Marcos González13, and Jesus F. San Miguel13 1 Department of Haematology, Molecular Biology, and Human Leukocyte Antigen (HLA) Unit, University Hospital of Salamanca; 2 Centro de Investigación del Cáncer (CIC) de Salamanca, Instituto de Biologia Molecular y Celular del Cancer (IBMCC; Universidad de Salamanca–Consejo Superior de Investigaciones Científicas [USAL-CSIC]); and 3 Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas (GEM/PETHEMA) We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome-wide association study was performed using 500 568 single nucleotide polymorphisms (SNPs) in 2 series of homogeneously treated MM patients, one with ONJ (22 MM cases) and another without ONJ (65 matched MM controls). Four SNPs (rs1934951, rs1934980, rs1341162, and rs17110453) mapped within the cytochrome P450-2C gene (CYP2C8) showed a different distribution between cases and controls with statistically significant differences (P = 1.07 x 10–6, P = 4.231 x 10–6, P = 6.22 x 10–6, and P = 2.15 x 10–6, respectively). SNP rs1934951 was significantly associated with a higher risk of ONJ development even after Bonferroni correction (P corrected value = .02). Genotyping results displayed an overrepresentation of the T allele in cases compared with controls (48% vs 12%). Thus, individuals homozygous for the T allele had an increased likelihood of developing ONJ (odds ratio 12.75, 95% confidence interval 3.7-43.5). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Genetic predisposition for the development of ONJ Evangelos Terpos and Meletios-Athanassios Dimopoulos Blood 2008 112: 2596-2597. [Full Text] [PDF]

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