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Blood, 1 September 2008, Vol. 112, No. 5, pp. 1600-1609.
Prepublished online as a Blood First Edition Paper on June 20, 2008; DOI 10.1182/blood-2008-04-152850.


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Review article

European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas

Nancy J. Senff1, Evert M. Noordijk2, Youn H. Kim3, Martine Bagot4, Emilio Berti5, Lorenzo Cerroni6, Reinhard Dummer7, Madeleine Duvic8, Richard T. Hoppe9, Nicola Pimpinelli10, Steven T. Rosen11, Maarten H. Vermeer1, Sean Whittaker12, and Rein Willemze1

Departments of 1 Dermatology and 2 Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands; Departments of 3 Dermatology and 9 Radiation Oncology, Stanford Comprehensive Cancer Center, Stanford, CA; 4 Department of Dermatology, Hôpital Henri Mondor, Créteil, France; 5 Department of Dermatology, University of Milan-Biococca and Fondazione Ospedale Policlinico, Regina Elena and Mangiagalli, Milan, Italy; 6 Department of Dermatology, University of Graz, Graz, Austria; 7 Department of Dermatology, University Hospital Zürich, Zürich, Switzerland; 8 Department of Dermatology, University of Texas M. D. Anderson Cancer Center, Houston; 10 Department of Dermatology, University of Florence, Florence, Italy; 11 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; and 12 Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, United Kingdom

Primary cutaneous B-cell lymphomas (CBCL) represent approximately 20% to 25% of all primary cutaneous lymphomas. With the advent of the World Health Organization-European Organization for Research and Treatment of Cancer (EORTC) Consensus Classification for Cutaneous Lymphomas in 2005, uniform terminology and classification for this rare group of neoplasms were introduced. However, staging procedures and treatment strategies still vary between different cutaneous lymphoma centers, which may be because consensus recommendations for the management of CBCL have never been published. Based on an extensive literature search and discussions within the EORTC Cutaneous Lymphoma Group and the International Society for Cutaneous Lymphomas, the present report aims to provide uniform recommendations for the management of the 3 main groups of CBCL. Because no systematic reviews or (randomized) controlled trials were available, these recommendations are mainly based on retrospective studies and small cohort studies. Despite these limitations, there was consensus among the members of the multidisciplinary expert panel that these recommendations reflect the state-of-the-art management as currently practiced in major cutaneous lymphoma centers. They may therefore contribute to uniform staging and treatment and form the basis for future clinical trials in patients with a CBCL.


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