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Blood, 1 August 2008, Vol. 112, No. 3, pp. 895-902. Prepublished online as a Blood First Edition Paper on May 22, 2008; DOI 10.1182/blood-2008-03-143735. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-03-143735v1 112/3/895    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Alessandrino, E. P. Articles by Bosi, A. PubMed PubMed Citation Articles by Alessandrino, E. P. Articles by Bosi, A. Related Collections Neoplasia Transplantation Free Research Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) Emilio Paolo Alessandrino1, Matteo Giovanni Della Porta1, Andrea Bacigalupo2, Maria Teresa Van Lint2, Michele Falda3, Francesco Onida4, Massimo Bernardi5, Anna Paola Iori6, Alessandro Rambaldi7, Raffaella Cerretti8, Paola Marenco9, Pietro Pioltelli10, Luca Malcovati1, Cristiana Pascutto1, Rosi Oneto2, Renato Fanin11, and Alberto Bosi12 1 Division of Hematology, University of Pavia, Fondazione Policlinico San Matteo, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia; 2 Division of Hematology, Ospedale San Martino, Genova; 3 Division of Hematology, Ospedale San Giovanni Battista, Torino; 4 Department of Hematology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano; 5 Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano; 6 Division of Hematology, Department of Cellular Biotechnologies and Hematology, University La Sapienza, Roma; 7 Division of Hematology, Ospedali Riuniti, Bergamo; 8 Hemato-Oncology Transplant Unit, University Tor Vergata, Roma; 9 Department of Hematology, Ospedale Niguarda Ca' Granda, Milano; 10 Division of Hematology and Transplant Unit, Ospedale San Gerardo, University of Milano-Bicocca, Monza; 11 Division of Hematology and Bone Marrow Transplantation, University of Udine, Udine; and 12 Department of Hematology, University of Florence, Florence, Italy We evaluated the impact of World Health Organization (WHO) classification and WHO classification–based Prognostic Scoring System (WPSS) on the outcome of patients with myelodysplastic syndrome (MDS) who underwent allogeneic stem cell transplantation (allo-SCT) between 1990 and 2006. Five-year overall survival (OS) was 80% in refractory anemias, 57% in refractory cytopenias, 51% in refractory anemia with excess blasts 1 (RAEB-1), 28% in RAEB-2, and 25% in acute leukemia from MDS (P = .001). Five-year probability of relapse was 9%, 22%, 24%, 56%, and 53%, respectively (P < .001). Five-year transplant-related mortality (TRM) was 14%, 39%, 38%, 34%, and 44%, respectively (P = .24). In multivariate analysis, WHO classification showed a significant effect on OS (P = .017) and probability of relapse (P = .01); transfusion dependency was associated with a reduced OS (P = .01) and increased TRM (P = .037), whereas WPSS showed a prognostic significance on both OS (P = .001) and probability of relapse (P < .001). In patients without excess blasts, multilineage dysplasia and transfusion dependency affected OS (P = .001 and P = .009, respectively), and were associated with an increased TRM (P = .013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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