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 Blood, 15 December 2007, Vol. 110, No. 13, pp. 4303-4311.
Prepublished online as a Blood First Edition Paper on September 10, 2007; DOI 10.1182/blood-2007-04-087486.

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IMMUNOBIOLOGY

CD74 induces TAp63 expression leading to B-cell survival

Frida Lantner1, Diana Starlets1, Yael Gore1, Liat Flaishon2, Ayala Yamit-Hezi3, Rivka Dikstein3, Lin Leng4, Richard Bucala4, Yossy Machluf2, Moshe Oren2, and Idit Shachar1

Departments of1 Immunology 2 Molecular Cell Biology, and 3 Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; and 4 Department of Medicine, Yale University School of Medicine, New Haven, CT

Most mature follicular B cells circulate within the periphery in a quiescent state, without actively contributing to an acute immune response. Lasting B-cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. We recently demonstrated that cell surface CD74 controls mature B-cell survival. Stimulation of cell surface CD74 leads to NF-{kappa}B activation, which enables entry of the stimulated B cells into the S phase, induction of DNA synthesis, and cell division, and augments the expression of survival genes. In the present study, we investigated CD74 target genes to determine the identities of the molecules whose expression is modulated by CD74, thereby regulating B-cell survival. We report that CD74 activates the p65 member of the NF-{kappa}B family, which in turn up-regulates the expression of p53-related TAp63 proteins. TAp63 then binds and transactivates the Bcl-2gene and induces the production of Bcl-2 protein, thereby providing the cells with increased survival capacity. Thus, the CD74/NF-{kappa}B/TAp63 axis defines a novel antiapoptotic pathway in mature B cells, resulting in the shaping of both the B-cell repertoire and the immune response.


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