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Prepublished online as a Blood First Edition Paper on September 12, 2002; DOI 10.1182/blood-2002-05-1392. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-05-1392v1 101/3/846    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hargrave, D. R. Articles by Kirkham, F. J. Search for Related Content PubMed PubMed Citation Articles by Hargrave, D. R. Articles by Kirkham, F. J. Related Collections Red Cells Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2003, Vol. 101, No. 3, pp. 846-848 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Brief report Nocturnal oxygen saturation and painful sickle cell crises in children Darren R. Hargrave, Angie Wade, Jane P. M. Evans, Deborah K. M. Hewes, and Fenella J. Kirkham From the Department of Paediatric Epidemiology and Biostatistics and from the Neurosciences Unit, Institute of Child Health; Great Ormond Street Hospital; and Department of Haematology, University College Hospital; all of London, United Kingdom; and Paediatric Oncology Unit, The Royal Marsden Hospital, Sutton, United Kingdom. The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, laboratory, and sleep study data and frequency of painful crisis was investigated. Both univariate and multiple regression modeling showed that low nocturnal oxygen saturation was highly significantly associated with a higher rate of painful crisis in childhood (P < .0001). Screening and treatment for hypoxemia may reduce the frequency of this and other complications of the disease. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. D. Pashankar, J. Carbonella, A. Bazzy-Asaad, and A. Friedman Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease Pediatrics, April 1, 2008; 121(4): 777 - 782. [Abstract] [Full Text] [PDF] K. R. Casey, K. O. Cantillo, and L. K. Brown Sleep-Related Hypoventilation/Hypoxemic Syndromes Chest, June 1, 2007; 131(6): 1936 - 1948. [Abstract] [Full Text] [PDF] J. H. Boyd, E. A. Macklin, R. C. Strunk, and M. R. DeBaun Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia Blood, November 1, 2006; 108(9): 2923 - 2927. [Abstract] [Full Text] [PDF] A K Siddiqui and S Ahmed Pulmonary manifestations of sickle cell disease Postgrad. Med. J., July 1, 2003; 79(933): 384 - 390. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020