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Prepublished online as a Blood First Edition Paper on September 26, 2002; DOI 10.1182/blood-2002-04-1183. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-04-1183v1 101/2/415    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Henderson, J. N. Articles by DeBaun, M. R. Search for Related Content PubMed PubMed Citation Articles by Henderson, J. N. Articles by DeBaun, M. R. Related Collections Red Cells Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2003, Vol. 101, No. 2, pp. 415-419 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle cell disease Jessica N. Henderson, Michael J. Noetzel, Robert C. McKinstry, Desiree A. White, Melissa Armstrong, and Michael R. DeBaun From the Department of Pediatrics, Division of Pediatric Hematology Oncology, Department of Neurology, Department of Pediatrics, Mallinkrodt Institute of Radiology, Neuroradiology, and Department of Psychology, Washington University School of Medicine, St Louis, MO. Patients with severe acute chest syndrome (ACS) requiring endotracheal intubation and erythrocytopheresis are at increased risk for neurologic morbidity. This study examines patients with sickle cell disease who developed severe episodes of ACS, leading to endotracheal intubation, ventilatory support for respiratory failure, and erythrocytapheresis. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) studies, a neurologic examination by a pediatric neurologist, and cognitive testing were done in all patients. Five consecutive patients, aged 3 to 9 years, were identified with severe ACS. All patients developed neurologic complications resulting from ACS episodes, including seizures (n = 2), silent cerebral infarcts (n = 3), cerebral hemorrhage (n = 2), and reversible posterior leukoencephalopathy syndrome (n = 3). Children with severe ACS should have a magnetic resonance image of the brain, neurologic examination by a neurologist, and cognitive testing to detect the presence of neurologic morbidity. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. J. Strouse, M. L. Hulbert, M. R. DeBaun, L. C. Jordan, and J. F. Casella Primary Hemorrhagic Stroke in Children With Sickle Cell Disease Is Associated With Recent Transfusion and Use of Corticosteroids Pediatrics, November 1, 2006; 118(5): 1916 - 1924. [Abstract] [Full Text] [PDF] S. T. Miller, S. P. Rao, J. H. Boyd, and M. R. DeBaun Acute chest syndrome, transfusion, and neurologic events in children with sickle cell disease Blood, August 15, 2003; 102(4): 1556 - 1557. [Full Text] [PDF]

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