|
|
Prepublished online as a Blood First Edition Paper on March 6, 2003; DOI 10.1182/blood-2002-12-3647.
 Previous Article | Table of Contents | Next Article 
Blood, 15 June 2003, Vol. 101, No. 12, pp. 4667-4679
REVIEW IN TRANSLATIONAL HEMATOLOGY
Map kinase signaling pathways and hematologic malignancies
Leonidas C. Platanias
From the Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL.
Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of Map kinases exist: the p38 Map kinase family, the extracellular signal-regulated kinase (Erk) family, and the c-Jun NH2-terminal kinase (JNK) family. The members of the different Map kinase groups participate in the generation of various cellular responses, including gene transcription, induction of cell death or maintenance of cell survival, malignant transformation, and regulation of cell-cycle progression. Depending on the specific family isoform involved and the cellular context, Map kinase pathways can mediate signals that either promote or suppress the growth of malignant hematopoietic cells. Over the last few years, extensive work by several groups has established that Map kinase pathways play critical roles in the pathogenesis of various hematologic malignancies, providing new molecular targets for future therapeutic approaches. In this review, the involvement of various Map kinase pathways in the pathophysiology of hematologic malignances is summarized and the clinical implications of the recent advances in the field are discussed.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
V. Levin-Salomon, K. Kogan, N. G. Ahn, O. Livnah, and D. Engelberg
Isolation of Intrinsically Active (MEK-independent) Variants of the ERK Family of Mitogen-activated Protein (MAP) Kinases
J. Biol. Chem.,
December 12, 2008;
283(50):
34500 - 34510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Yoda, K. Toyoshima, Y. Watanabe, N. Onishi, Y. Hazaka, Y. Tsukuda, J. Tsukada, T. Kondo, Y. Tanaka, and Y. Minami
Arsenic Trioxide Augments Chk2/p53-mediated Apoptosis by Inhibiting Oncogenic Wip1 Phosphatase
J. Biol. Chem.,
July 4, 2008;
283(27):
18969 - 18979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Briot, G. Mace-Aime, F. Subra, and F. Rosselli
Aberrant activation of stress-response pathways leads to TNF-{alpha} oversecretion in Fanconi anemia
Blood,
February 15, 2008;
111(4):
1913 - 1923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. de Totero, R. Meazza, M. Capaia, M. Fabbi, B. Azzarone, E. Balleari, M. Gobbi, G. Cutrona, M. Ferrarini, and S. Ferrini
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
Blood,
January 15, 2008;
111(2):
517 - 524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nefedova, M. Fishman, S. Sherman, X. Wang, A. A. Beg, and D. I. Gabrilovich
Mechanism of All-Trans Retinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells
Cancer Res.,
November 15, 2007;
67(22):
11021 - 11028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Sze, D. P. V. de Kleijn, R. C. Lai, E. Khia Way Tan, H. Zhao, K. S. Yeo, T. Y. Low, Q. Lian, C. N. Lee, W. Mitchell, et al.
Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells
Mol. Cell. Proteomics,
October 1, 2007;
6(10):
1680 - 1689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dasmahapatra, N. Yerram, Y. Dai, P. Dent, and S. Grant
Synergistic Interactions between Vorinostat and Sorafenib in Chronic Myelogenous Leukemia Cells Involve Mcl-1 and p21CIP1 Down-Regulation
Clin. Cancer Res.,
July 15, 2007;
13(14):
4280 - 4290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gregorj, M. R. Ricciardi, M. T. Petrucci, M. C. Scerpa, F. De Cave, P. Fazi, M. Vignetti, A. Vitale, M. Mancini, G. Cimino, et al.
ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Blood,
June 15, 2007;
109(12):
5473 - 5476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rizzi, M. P. Tschan, C. Britschgi, A. Britschgi, B. Hugli, T. J. Grob, N. Leupin, B. U. Mueller, H.-U. Simon, A. Ziemiecki, et al.
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells
J. Leukoc. Biol.,
June 1, 2007;
81(6):
1599 - 1608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. K. Nguyen, M. Rahmani, H. Harada, P. Dent, and S. Grant
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825
Blood,
May 1, 2007;
109(9):
4006 - 4015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. J. E. Tissing, M. L. den Boer, J. P. P. Meijerink, R. X. Menezes, S. Swagemakers, P. J. van der Spek, S. E. Sallan, S. A. Armstrong, and R. Pieters
Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells
Blood,
May 1, 2007;
109(9):
3929 - 3935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Jin, Y. Yamazaki, M. Takuwa, T. Takahara, K. Kaneko, T. Kuwata, S. Miyata, and T. Nakamura
Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
Blood,
May 1, 2007;
109(9):
3998 - 4005.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Grinstein, Y. Du, S. Santourlidis, J. Christ, M. Uhrberg, and P. Wernet
Nucleolin Regulates Gene Expression in CD34-positive Hematopoietic Cells
J. Biol. Chem.,
April 27, 2007;
282(17):
12439 - 12449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kojima, M. Konopleva, I. J. Samudio, V. Ruvolo, and M. Andreeff
Mitogen-Activated Protein Kinase Kinase Inhibition Enhances Nuclear Proapoptotic Function of p53 in Acute Myelogenous Leukemia Cells
Cancer Res.,
April 1, 2007;
67(7):
3210 - 3219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Zhang, K. A. Kernan, S. J. Collins, X. Cai, J. M. Lopez-Guisa, J. L. Degen, Y. Shvil, and A. A. Eddy
Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals
J. Am. Soc. Nephrol.,
March 1, 2007;
18(3):
846 - 859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Milella, M. Konopleva, C. M. Precupanu, Y. Tabe, M. R. Ricciardi, C. Gregorj, S. J. Collins, B. Z. Carter, C. D'Angelo, M. T. Petrucci, et al.
MEK blockade converts AML differentiating response to retinoids into extensive apoptosis
Blood,
March 1, 2007;
109(5):
2121 - 2129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Mhaidat, X. D. Zhang, C. C. Jiang, and P. Hersey
Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH2-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway
Clin. Cancer Res.,
February 15, 2007;
13(4):
1308 - 1314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Bugarski, A. Krstic, S. Mojsilovic, M. Vlaski, M. Petakov, G. Jovcic, N. Stojanovic, and P. Milenkovic
Signaling Pathways Implicated in Hematopoietic Progenitor Cell Proliferation and Differentiation
Experimental Biology and Medicine,
January 1, 2007;
232(1):
156 - 163.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Huang, S. Bu, Y. Yu, Z. Guo, G. Ghatnekar, M. Bu, L. Yang, B. Lu, Z. Feng, S. Liu, et al.
Diazoxide Prevents Diabetes through Inhibiting Pancreatic {beta}-Cells from Apoptosis via Bcl-2/Bax Rate and p38-{beta} Mitogen-Activated Protein Kinase
Endocrinology,
January 1, 2007;
148(1):
81 - 91.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Navas, M. Mohindru, M. Estes, J. Y. Ma, L. Sokol, P. Pahanish, S. Parmar, E. Haghnazari, L. Zhou, R. Collins, et al.
Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors
Blood,
December 15, 2006;
108(13):
4170 - 4177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Grabbe and J. Wienands
Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes
Blood,
December 1, 2006;
108(12):
3761 - 3768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Capra, P. G. Nuciforo, S. Confalonieri, M. Quarto, M. Bianchi, M. Nebuloni, R. Boldorini, F. Pallotti, G. Viale, M. L. Gishizky, et al.
Frequent Alterations in the Expression of Serine/Threonine Kinases in Human Cancers
Cancer Res.,
August 15, 2006;
66(16):
8147 - 8154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kannan-Thulasiraman, E. Katsoulidis, M. S. Tallman, J. S. C. Arthur, and L. C. Platanias
Activation of the Mitogen- and Stress-activated Kinase 1 by Arsenic Trioxide
J. Biol. Chem.,
August 11, 2006;
281(32):
22446 - 22452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chakrabarty, W. Wu, J. L. Booth, E. S. Duggan, K. M. Coggeshall, and J. P. Metcalf
Bacillus anthracis Spores Stimulate Cytokine and Chemokine Innate Immune Responses in Human Alveolar Macrophages through Multiple Mitogen-Activated Protein Kinase Pathways.
Infect. Immun.,
August 1, 2006;
74(8):
4430 - 4438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. de Melo, M. W. Gerbase, J. Curran, and J.-C. Pache
Phosphorylated Extracellular Signal-regulated Kinases Are Significantly Increased in Malignant Mesothelioma
J. Histochem. Cytochem.,
August 1, 2006;
54(8):
855 - 861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Giafis, E. Katsoulidis, A. Sassano, M. S. Tallman, L. S. Higgins, A. R. Nebreda, R. J. Davis, and L. C. Platanias
Role of the p38 Mitogen-Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide-Dependent Cellular Responses.
Cancer Res.,
July 1, 2006;
66(13):
6763 - 6771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gupta, S. K. Gupta, B. Hoffman, and D. A. Liebermann
Gadd45a and Gadd45b Protect Hematopoietic Cells from UV-induced Apoptosis via Distinct Signaling Pathways, including p38 Activation and JNK Inhibition
J. Biol. Chem.,
June 30, 2006;
281(26):
17552 - 17558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zebisch, P. B. Staber, A. Delavar, C. Bodner, K. Hiden, K. Fischereder, M. Janakiraman, W. Linkesch, H. W. Auner, W. Emberger, et al.
Two Transforming C-RAF Germ-Line Mutations Identified in Patients with Therapy-Related Acute Myeloid Leukemia.
Cancer Res.,
April 1, 2006;
66(7):
3401 - 3408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. S. Radomska, D. S. Basseres, R. Zheng, P. Zhang, T. Dayaram, Y. Yamamoto, D. W. Sternberg, N. Lokker, N. A. Giese, S. K. Bohlander, et al.
Block of C/EBP{alpha} function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
J. Exp. Med.,
February 21, 2006;
203(2):
371 - 381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. R. Hundley and B. Rigas
Nitric Oxide-Donating Aspirin Inhibits Colon Cancer Cell Growth via Mitogen-Activated Protein Kinase Activation
J. Pharmacol. Exp. Ther.,
January 1, 2006;
316(1):
25 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Seong, C. Park, C. Y. Kim, Y. J. Hong, H.-S. So, S.-D. Kim, and R. Park
Mitomycin-C Induces the Apoptosis of Human Tenon's Capsule Fibroblast by Activation of c-Jun N-Terminal Kinase 1 and Caspase-3 Protease
Invest. Ophthalmol. Vis. Sci.,
October 1, 2005;
46(10):
3545 - 3552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Katsoulidis, Y. Li, P. Yoon, A. Sassano, J. Altman, P. Kannan-Thulasiraman, L. Balasubramanian, S. Parmar, J. Varga, M. S. Tallman, et al.
Role of the p38 Mitogen-Activated Protein Kinase Pathway in Cytokine-Mediated Hematopoietic Suppression in Myelodysplastic Syndromes
Cancer Res.,
October 1, 2005;
65(19):
9029 - 9037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hachem and R. B. Gartenhaus
Oncogenes as molecular targets in lymphoma
Blood,
September 15, 2005;
106(6):
1911 - 1923.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-T. Chang, C.-M. Tsai, Y.-C. Chiou, C.-H. Chiu, K.-S. Jeng, and C.-Y. F. Huang
IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells
Am J Physiol Lung Cell Mol Physiol,
September 1, 2005;
289(3):
L446 - L453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Li-Weber, M. K. Treiber, M. Giaisi, K. Palfi, N. Stephan, S. Parg, and P. H. Krammer
Ultraviolet Irradiation Suppresses T Cell Activation via Blocking TCR-Mediated ERK and NF-{kappa}B Signaling Pathways
J. Immunol.,
August 15, 2005;
175(4):
2132 - 2143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Petlickovski, L. Laurenti, X. Li, S. Marietti, P. Chiusolo, S. Sica, G. Leone, and D. G. Efremov
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
Blood,
June 15, 2005;
105(12):
4820 - 4827.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Miller, M. S. Webb, A. J. Copik, Y. Wang, B. H. Johnson, R. Kumar, and E. B. Thompson
p38 Mitogen-Activated Protein Kinase (MAPK) Is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211
Mol. Endocrinol.,
June 1, 2005;
19(6):
1569 - 1583.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Zhu, G. Somlo, B. Zhou, J. Shao, V. Bedell, M. L. Slovak, X. Liu, J. Luo, and Y. Yen
Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma
Mol. Cancer Ther.,
May 1, 2005;
4(5):
787 - 798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Huang, S. Chen, L. Xu, Y. Liu, D. K. Deb, L. C. Platanias, and R. C. Bergan
Genistein Inhibits p38 Map Kinase Activation, Matrix Metalloproteinase Type 2, and Cell Invasion in Human Prostate Epithelial Cells
Cancer Res.,
April 15, 2005;
65(8):
3470 - 3478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, S. Batra, A. Sassano, B. Majchrzak, D. E. Levy, M. Gaestel, E. N. Fish, R. J. Davis, and L. C. Platanias
Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons
J. Biol. Chem.,
March 18, 2005;
280(11):
10001 - 10010.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
