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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by COWDELL, R. H. Articles by PYKE, D. A. Search for Related Content PubMed PubMed Citation Articles by COWDELL, R. H. Articles by PYKE, D. A. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1955, Vol. 10, No. 8, pp. 788-801. © 1955 American Society of Hematology, Inc. Constitutional Anemia (Fanconi’s Syndrome) and Leukemia in Two Brothers R. H. COWDELL , P. J. R. PHIZACKERLEY , and D. A. PYKE Two brothers physically very alike became ill in their third decade, one with severe bone marrow hypoplasia and the other with acute leukemia. Both died and the autopsy findings are described. The two shared certain congenital defects, notably short stature with small heads, cutaneous pigmentation, pituitary and genital hypoplasia, and deformity of the thumbs. The brother with hypoplastic anemia also had aortic hypoplasia and his left kidney was absent. No previous report has been discovered of the association of Fanconi’s syndrome (of bone marrow hypoplasia with congenital defects) and leukemia with similar congenital defects in brothers. In two reports of leukemia affecting cousins of patients with Fanconi's syndrome, the leukemic cousins were without congenital defects. Submitted on November 16, 1954 Accepted on January 28, 1955 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. N. COLE, H. N. COLE Jr., and W. P. LASCHEID Dyskeratosis Congenita: Relationship to Poikiloderma Atrophicans Vasculare and to Aplastic Anemia of Fanconi Arch Dermatol, December 1, 1957; 76(6): 712 - 719. [Abstract] [PDF]

	Copyright © 1955 by American Society of Hematology         Online ISSN: 1528-0020