Blood, 1955, Vol. 10, No. 5, pp. 441-452.
© 1955 American Society of Hematology, Inc.
The Adrenal Cortex and Hemolysis
III. Peripheral Blood Cell Reactions
J. D. FELDMAN 1,
M. RACHMILEWITZ 1, and
O. STEIN 1
1 Department of Pathology and Medical Department "B" of the Hebrew University-Hadassah Medical School and the Hadassah Hospital, Jerusalem, Israel.
Hemolysis was induced in rats by the intravenous administration of phenylhydrazine, immune hemolytic serum and Tween 80. During the period of red
cell destruction, which lasted for three to four days, there was a marked leukocytosis, neutrophilia and eosinophilia which also persisted for three to four days.
With phenylhydrazine and Tween 80 there was an initial transitory eosinopenia;
with immune serum there was an immediate eosinophilia.
In contrast, anemia produced by cardiac hemorrhage was accompanied by a
transient slight leukocytosis and eosinopenia. Within one day the white cell
level returned to baseline levels, but eosinophilia appeared and persisted for two
days. The injections of formaldehyde, ACTH, and saline, and cardiac puncture
without bleeding caused a slight ephemeral leukocytosis and eosinopenia.
The peripheral blood cell response observed during hemolysis occurred in the
presence or absence of the adrenals, and with or without the administration of
ACTH.
It was concluded that hemolysis elicits a distinct pattern of cellular response
in the peripheral blood which is not mediated through the adrenal cortex.
Submitted on July 23, 1954
Accepted on September 23, 1954
