Blood, 1955, Vol. 10, No. 2, pp. 120-131.
© 1955 American Society of Hematology, Inc.
Plasma Thromboplastin Antecedent (PTA) Deficiency:
Clinical, Coagulation, Therapeutic and Hereditary
Aspects of a New Hemophilia-like Disease
ROBERT L. ROSENTHAL 1,
O. HERMAN DRESKIN 1, and
NATHAN ROSENTHAL 1
1 Laboratories of the Levy Foundation, Beth Israel Hospital, New York, N. Y.
and the Dept. of Internal Medicine and Pathology, Jewish Hospital, Cincinnati, Ohio.
1. An analysis of the original PTA deficient family, including coagulation
studies performed upon 13 members comprising 4 generations, has been presented.
2. PTA deficiency is transmitted as an autosomal dominant trait with a probable high degree of penetrance and variable expression of the gene.
3. PTA deficiency can occur its varying degrees ranging from a severe form
with prolonged clotting time and markedly abnormal heparin clotting time and
prothrombin utilization to a mild form manifesting a normal clotting time and
slightly impaired prothrombin utiliztition.
4. Studies on the treatment of PTA deficiency reveal that the defect is corrected by the administration of stored plasma with the effect gradually disappearing over the period of one week.
5. Various properties of PTA are discussed and compared with AHG and
PTC.
Submitted on April 27, 1954
Accepted on July 6, 1954
