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Blood, 1946, Vol. 1, No. 5, pp. 379-386.
© 1946 American Society of Hematology, Inc.

CELLULAR CHANGES PRODUCED BY EXTRACTS OF HUMAN ORGANS

L. A. ERF M.D.1, D. L. TURNER PH.D.1, and F. R. MILLER M.D.1

1 Charlotte Drake Cardeza Foundation, Jefferson Medical College and Hospital, Philadelphia, Pa.

By the injection of lipoid extracts of organs (liver, spleen, and lymph nodes) of 5 patients with leukemia, 1 with Hodgkin's disease, and of 4 "control" cases (3 of heart disease and 1 of cerebral tumor) into 28 guinea-pigs, it was observed that:

a. extracts from human myeloid leukemic organs produced "myeloid reactions" or infiltrations in guinea-pigs;

b. extracts from lymphoid leukemic organs produced "lymphoid reactions";

c. extracts from organs involved with Hodgkin's disease produced "Hodgkin's reactions"; and

d. extracts from "normal" organs produced slight lymphoid or monocytoid infiltrations.


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