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1 Department of Obstetrics and Gynecology, New York University College of Medicine;
the Obstetrical and Gynecologic Service of the Third (New York University) Surgical Division of Bellevue Hospital, and the Serological Laboratory of the Office of the Chief Medical Examiner of New York
City.
1. The titers of the isoagglutinins anti-A and anti-B in pregnant women at term
do not differ significantly from the isoagglutinin titers in normal male adult blood
donors. This indicates that pregnancy itself does not ordinarily stimulate a rise
in isoagglutinin titer. 2. The frequency of incompatible blood groups in the infants of 31 mothers
with toxemia of pregnancy was slightly higher (29 per cent) than that in a series
of 166 infants of mothers without toxemia (22.3 per cent), but the difference was
not statistically significant. 3. Of 37 normal mothers whose infants had blood groups incompatible with
theirs, 9 were found to have a significant rise in isoagglutinin titer one week post
partum. An appreciable rise in isoagglutinin titer occurred under similar circumstances in 6 of 9 mothers with toxemia. The series are too small to permit definite
conclusions regarding the significance of this in relation to toxemia. However,
there appears to be no doubt that under certain circumstances parturition can stimulate a rise in the maternal isoagglutinin titer. 4. No correlation was found between the occurrence of Rh incompatibility and
toxemia of pregnancy. 5. The data obtained furnish additional evidence to support the theory of
multiple allelic genes of heredity of the Rh blood types and also Race and Taylor’s
theory of inheritance of the Hr factor.
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| Copyright © 1946 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
