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Blood, 1946, Vol. 1, No. 3, pp. 189-201.
© 1946 American Society of Hematology, Inc.

ACUTE HEMOLYTIC ANEMIA AND HEMOGLOBINURIA FOLLOWING SULFADIAZINE MEDICATION

REPORT OF A CASE

JOSEPH F. ROSS M.D.1 and BERTHA L. PAEGEL M.D.1

1 Robert Dawson Evans Memorial, Massachusetts Memorial Hospitals, the Department of Medicine, Boston University School of Medicine, and the Department of Biological Chemistry, Harvard Medical School. Prepared under tenure of a Welch Fellowship in Internal Medicine of the National Research Council.

1. A case of acute hemolytic anemia with hemoglobinuria precipitated by sulfadiazine is described.

2. Spherocytosis and increased hypotonic saline fragility were demonstrated during the acute phase of the disease.

3. Abnormal hemagglutinins and hemolysins were not present in the patient's serum.

4. The significance of these findings as related to the etiology of the disease is discussed.


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